Scientists in Colombia have identified a highly diversified new SARS-CoV-2 line with substitutes Spike L249S and E484K. These same mutations have appeared concomitantly in other mutant sequences of the virus, especially in anxiety mutations.
A pre-printed version of the full research paper can be found on the medRxiv* server.
The rapid spread and RNA nature of acute respiratory coronavirus 2 (SARS-CoV-2) syndrome has allowed mutant mutations to occur. Although only a few routine changes are a real concern over the underlying virus, to date, more than 800 lines have been reported, many of which are progressing with the same mutations or -dependent of each other.
Katherine Laiton-Donato and her colleagues in Colombia have now followed a new variable range, with mutations including the Spike L249S and E484K centers.
Both of these substitutions are thought to be related to immune escape. The presence of E484K is thought to be primarily responsible for the inhibition of antibodies from convalescent blood plasma. Both of these mutations are related to lines B.1.1.28 and B.1.351 (the Brazilian and South African variables, respectively), two types of concern.
The team used the Pangolin algorithm – a database of SARS-CoV-2 registered genomes – to determine the origin for the new Colombian series. The algorithm identified the webline as part of line B.1.111, which was first identified in the U.S. in early March 2020. This variant is currently circulating in Colombia, the USA, Aruba, and Belgium. The most likely phylogenetic tree was also used to estimate parental lineage. These results also supported B.1.111 parents. Other mutations in the series are also consistent with this idea.
Despite this consensus, many notable mutations are still present in the newly identified snoring that differs from B.1.111. The authors state that a larger sample size could continue to support B.1.111 parenting. However, another explanation is that these mutations may have arisen abruptly from intense ecological pressures, which are currently unknown.
The L249S and E484K substrates have been shown to be consistent in nearly 70 identified species, which is not entirely surprising as these are thought to be associated with antibody protection.
The rapid emergence of viral strains resistant to antibody will challenge the current global immunization program, as mutations such as L249S and E484K may occur in any local population. within any country from time to time.
The authors conclude, “In the context of pandemic spread of the virus, a large amount of virus is expected, as it also reveals virus changes that may reveal antibody-resistant mutants. in the context of natural infection. in immunocompetent humans. The impact of this genetic background on the effectiveness of convalescent serum / plasma neutralization from acquired immunity needs to be evaluated. ”