It may be possible two completely different shots of COVID-19, doctors have warned in the journal BMJ Case Reports after treatment by a man who had the infections isolated by 4 months without symptoms and serial negative tests for the virus.
Degenerative immunity may increase the risk of relapse, but severe infections may initially lead to milder symptoms the second time, they suggest.
It is not known for humans to be reactivated by SARS-CoV-2, the virus responsible for COVID-19 infection, but very few cases have been reported. And it is not yet clear whether this actually represents continuous viral shedding rather than a true redefinition.
In an effort to shed some light on this, the authors report the case of a man in his 40s who was admitted to hospital with moderate COVID-19 infection 4 months after the first stroke of the disease. April 2020.
Man had well-controlled type 2 diabetes, an underactive thyroid gland, and was obese – known risk factors for severe COVID-19 disease.
The first time around, she was admitted to the hospital with respiratory problems and a high-capped wheel caused by a turbulent airflow, called a stridor.
He developed respiratory failure, and required mechanical ventilation and blood thinners as well as several other drugs used to treat COVID-19.
He was hospitalized for 2 months and developed severe complications, including hospital-acquired infection (MRSA), gastrointestinal bleeding, severe shower-related seizures and renal failure. When he settled, he was sent to an intensive care facility for rehabilitation.
For the second time around in August 2020, he tested positive for SARS-CoV-2, after four interim negative tests in the previous three months. He stayed in the hospital for just 1 day.
Two weeks later she was admitted to hospital with shortness of breath; he told doctors he had choked times from choking, shortness of breath, and cramps. The third hospital stay lasted a week.
Again, he tested positive for SARS-CoV-2, claiming that he had little knowledge of others, except relatives and close family who had no symptoms and had not been diagnosed. being ill recently.
As an explanation for the positive test results several months apart, the authors suggest that this may be due to reinterpretation by the virus. The second milder symptoms may be due to immunity from the first major infection, they add.
The Centers for Disease Control and Prevention (CDC) suggests that a SARS-CoV-2 positive swab test within 90 days of initial infection may represent persistent viral excretion rather than recurrence, the the authors say.
But they point out: “As the COVID-19 pandemic has progressed, emerging reports have shown that it is possible to redefine SARS-CoV-2, in order to long-term positive SARS-CoV-2 RNA test does not consistently show viral shedding from previous COVID-19 infection. ”
And they speculate: “If patients with a very severe disease develop stronger antibody levels, the time it takes to protect them against relapse and the severity of the disease, if it does occur, could certainly future ideas throw more light on this if this idea holds true.
“The presence or absence of antibodies after initial infection in survivors of the first program of COVID-19 and its role in mitigating the risk of SARS-relapse play no role CoV-2 is clearly defined.It is plausible, however, that a decline in immunity or the absence of antibodies after the first episode of SARS CoV-2 infection may make one more likely to relapse. Interpretation. “
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External peer review? Yes
Type of evidence: Single case report
Subjects: People
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