The co-directed researchers will consider the first upcoming study to evaluate long-term outcomes on MIS-C patients.
Heart involvement – including ventricular dysfunction, coronary artery dilation and aneurysms, among others – has been a key feature in many cases of multisystemic inflammatory disease in children (MIS-C). .
Although most patients recover within days or weeks, long-term results are not currently known.
The Long-Term Results After the Multisystem Inflammatory Syndrome in Children (MUSIC) study is the first of these trials to examine the effects of MIS-C on coronary anatomy as well as ventricular function over time. The study also monitors the long-term effects of the recently discovered syndrome on the nervous, lung, immune and gastrointestinal systems.
Co-led by pediatric cardiologists Dongngan Truong, MD, University Hospital of Utah and Intermountain Primary Hospital, and Jane Newburger, MD, Boston Children’s Hospital, the 5-year longitudinal study is currently underway enrollment of approximately 600 patients diagnosed with MIS- C and recovered in addition to those who develop MIS-C over the next 2 years.
The researchers will analyze potential risk factors through the assessment of changes in cardiac function and genetic predisposition, among many other activities.
The ultimate goal of the study is to find and provide critical information to pediatricians and relevant parties in order to provide the best possible treatment and care for these patients.
“It can be a scaffold for other studies,” Newburger said HCPLive® in an interview. “If rheumatologists, or neurologists, or other specialists who want to look deeper into a test, can build on the framework of this study if they want. ”