She was put down, questioned and rejected. Now, her work is based on the Covid-19 vaccine

Covid-19 vaccines are beginning to be distributed in several countries, a progressive outbreak that hopes to signal light at the end of this dark pandemic. For Katalin Karikó, the moment is particularly special.

Karikó has spent decades of her career exploring the therapeutic potential of mRNA, a component of DNA that is considered one of the key building blocks in life. Through many obstacles, job losses, doubt and movement across the ocean, Karikó stood by her conviction: mRNA could be used for something truly innovative. Now, that work is the basis of the Covid-19 vaccine.

From Hungary to the USA

Karikó, 65, began her career in native Hungary in the 1970s, when new mRNA research and opportunities looked endless. But the call of the American dream began (and more research and funding opportunities).

In 1985, she and her husband and young daughter left Hungary for the USA after receiving an invitation from Temple University in Philadelphia. They sold their car, Karikó told the Guardian, and filled the money – equivalent to about $ 1,200 – in their daughter’s teddy to keep it safe.

“We had just moved into our new flat, our daughter was 2 years old, everything was so good, we were happy,” Karikó told the Hungarian news site G7 when her family left. “But we had to go.”

She continued her research at Temple, and then at the University of Pennsylvania School of Medicine. But by then, the flower was off the rose of an mRNA study, and Karikó’s idea that it could be used to fight disease was considered too radical, too financially risky to fund. She applied for grant after grant, but continued to receive a rejection, and in 1995, she was fired at UPenn. He was also diagnosed with cancer around the same time.

“Usually, at that stage, people just say goodbye and leave because it’s so horrible,” she told Stat, a health news site, in November. “I thought about going somewhere else, or doing something else. I also thought I might not be good enough, I’m not strong enough. ”

From doubt to bankruptcy

But she grabbed him.

Finally, Karikó and her former colleague at the University of Pennsylvania, Drew Weissman, developed a method of using synthetic mRNA to fight disease that involves altering the way the body makes material. virus fight, she explained on CNN’s “Cuomo Prime Time”.

That discovery is now the basis of the Covid-19 vaccine, and some have said that both Weissman and Karikó, who is now senior vice president of BioNTech, are based in the Germany, worthy of the Nobel Prize.

“If anyone asks me who to vote for someday, I would put them in front and in the middle,” Derek Rossi, one of the founders of the medicine giant Moderna, told Stat. “That basic discovery goes into medicines that help the world. ”

While recognition, after all this time, has to be nice, Karikó says it’s not scientific glory that’s on her mind right now.

“Indeed, we will be celebrating when this human suffering will end, when this hardship and terrible time will come to an end, and hopefully in the summer when we forget about viruses and vaccines. And then I celebrate a lot, ”she told CNN’s Chris Cuomo.

Karikó said she plans to get the vaccine soon, along with Weissman, and said she is “very, very confident” it will work. In fact, it was their findings that contributed to it.

Meanwhile, Karikó said she gave herself a little permission to celebrate the news of the vaccine: a bag of Goobers, her favorite candy.