Finn Russell is being ruled for Scotland after suffering a decision in the case with Ireland, which sees Stuart Hogg start at No. 10 for the first time, along with Scott Steele from Harlequins at second half. There are seven changes in total for Scotland: Darcy Graham starts on the wing, Sean Maitland changes to full-back and Huw Jones, who scored a stunning goal after coming off the bench last week. , appearing at the outer center. David Cherry makes his Scottish debut at the hook, Zander Fagerson returns at propheadhead, and there is also a second new series by Sam Skinner and Grant Gilchrist.
Four changes for Italy with Edoardo Padovani, Federico Mori, Federico Ruzza and Marco Riccioni entering the starting XV.
Scotland: Sean Maitland; Darcy Graham; Huw Jones, Sam Johnson; Duhan Van der Merwe; Stuart Hogg, Scott Steele; Rory Sutherland, David Cherry, Zander Fagerson; Sam Skinner, Grant Gilchrist, Jamie Ritchie, Hamish Watson, Matt Fagerson. Transplants: George Turner, Jamie Bhatti, Simon Berghan, Alex Craig, Nick Haining, Ali Price, Jaco Van der Walt, Chris Harris.
Italy: Edoardo Padovani; Mattia Bellini, Juan Ignacio Brex, Federico Mori, Montana Ioane; Paolo Garbisi, Stephen Varney; Danilo Fischetti, Luca Bigi (captain), Marco Riccioni, Niccolo Cannone, Federico Ruzza, Sebastian Negri, Johan Meyer, Michele Lamaro. Transplants: Gianmarco Lucchesi, Andrea Lovotti, Giosuè Zilocchi, Riccardo Favretto, Maxime Mbanda, Marcello Violi, Carlo Canna, Marco Zanon.