Researchers summarize basic mechanisms and applications of sonoporation in cell regulation

Announcing the publication of a new article for BIO integration iris. In this review article the authors Yue Li, Zhiyi Chen and Shuping Ge from the First Associated Hospital of the University of South China, Hengyang, China and Tower Health and Drexel University, Philadelphia, PA, USA present summary of modern conventional applications of microbubble-cell. interactions and effects of sonoporation to cell functions.

Ultrasound combined with microbubble centralized sonoporation was performed to enhance intracellular drug or gene delivery. Sonoporation leads to the formation of openings in the cell membrane, stimulated by ultrasound-mediated oscillations and the destruction of microbubbles.

Multiple mechanisms involved in sonoporation occur, including ultrasonic parameters, microbubbles size, and microbubbles speed to cells. Recent advances are beginning to expand applications through the support of interface agents, which allow ultrasound to directly link to cell functions such as gene expression, cell apoptosis, differentiation, and even epigenetic remodeling.