A researcher from the University of Missouri found a new way to help the body ‘s immune system overcome that deception and destroy cancer.
“Normally, your body’s immune cells are always on patrol to identify and destroy foreign bodies in the body,” said Yves Chabu, assistant professor in the Department of Biological Sciences.
“Normal cells put up a ‘don’t-eat-me’ molecular flag known to immune cells, thus preventing the destruction of normal figs. But some cancers also have the ability to imitating normal cells and making the ‘don’ of this t ith me ‘signal.As a result, the immune system does not recognize cancer as a deficient substance and leaves it alone, which is the bad news for the patient, “Chabu said.
Immunotherapies are cancer drugs that largely block the “don’t-eat-me” signal that comes from cancer and allow the immune system to killed.
Chabu, who holds a position in the College of Arts and Science, said that while these vaccines work for certain types of cancers, prostate cancer is highly immune, resulting in both physical and molecular environments the cancer just gets the upper hand on the body ‘s immune system.
But Chabu may have solved a solution with the help of more than 50-year-old bacteria species.
“Cancers are different in one person to the next, even when they affect the same substance. These interpersonal differences contribute to whether or not a particular treatment eliminates the cancer. effectively and help the patient. The bacteria themselves are genetically flexible, so it can be genetically modified to overcome patients’ specific therapeutic limits, “Chabu said.
“Imagine a patient whose cancer does not respond to traditional treatments and who has no other treatment options. One can think that he is genetically modifying the bacteria so that he can download a medication that takes advantage. specifically on cancer-specific vulnerability and killing, ”Chabu said.
In a previous study, scientists at the Cancer Research Center and the University of Missouri developed a specific and non-toxic genetic strain of salmonella called CRC2631 to select and kill cancer cells.
CRC2631 was derived from another strain of salmonella that was stored at room temperature for more than half a century. Now, scientists like Chabu are revealing the ability of CRC2631, which is actively targeting cancerous tumors, to be used to boost the body ‘s immune system against prostate cancer.
“Because CRC2631 favorably colonizes tumor cells, the effect is localized to the tumor. The use of CRC2631 to design and deliver patient-designed treatment predicts potential in precision treatment, or the ability to tailor treatment to a specific patient, “Chabu said.
Demonstrating the promise of personalized health care and the impact of large-scale interdisciplinary collaboration, the University of Missouri’s NextGen Precision Health initiative brings together innovators from across the system’s four research universities to become seeking detailed life-changing health improvements.
It is a collaborative effort to accelerate the strengths of Mizzou and the entire UM System toward a better future for Missouri health. An important part of the initiative is the construction of the new NextGen Precision Health building, which will expand collaboration between researchers, clinicians and industry leaders in a state-of-the-art research facility.
This story was published from a wire group group with no text changes.
