Researchers are developing a new way to regenerate bone and heal heavy wounds

Researchers at Lund University in Sweden, in collaboration with colleagues in Dresden, Germany, have developed a method to combine bone substitute and drugs to regenerate bone and bones. large cures in that thigh or bone. The study, published in the research journal Advances in science, made on rats, but the researchers believe that the method will soon be in different compounds in clinical settings.

The drugs and substances we used in the study for bone regeneration have already been agreed. We just packed them in a new combination. Therefore, there are no real barriers to using the method already in clinical trials for some major bone defects that are difficult to resolve in patients. But we want to introduce this method in a controlled form through clinical studies and have recently received ethical approval. “

Deepak Raina, Lead study author, Researcher Orthopedics, Lund University

Bones in the human body have a unique ability to repair an injury, but some defects are so severe or complex that the healing process is delayed or absent. This could be because the bone has been severely strained in connection with a traffic accident for example, or a tumor or disease causing a major bone defect. These cases are currently treated through bone transplantation, usually with bone removed from the patient’s own pelvis.

“In cases involving an open fracture in the lower leg, more than 5 percent of all fractures fail. With our approach, we will be able to avoid bone from the lower leg. pelvis, which is a great benefit to the patient. “

New solutions are needed and several research teams, both in Europe and the US, are working on developing a bone healing process. To date, the injectable cocktail has been successfully blended by Swedish and German researchers made up of three components: Lund-developed artificial ceramic material, bioactive bone protein (rhBMP-2) and drug, bisphosphonate, which fights against bone.

“The bone protein we use in previous studies has been adversely affected by premature bone resorption, among other things. We have successfully reduced this effect with the bisphosphonate and, by packing the drug in a slowly regenerating bone center, we can control the rate of release.In the present study with the mixture, we achieved a reduction of six- complex in the amount of protein compared to previous attempts, while still promoting bone formation.The result was that even a fracture with a widespread bone defect could be cured without complications.We believe that this finding will great clinical need in the future, ”says Deepak Raina.