Non-traditional movement schedules lead to higher rates of kidney failure and injury

Disruption of organ rhythms caused by shift work is a major factor in the development of injury-induced disease, according to a new research article published in the America Journal of Physiology-Renal Physiology. Scientists mimicked the movement agenda in rats and found that it not only caused a slowdown in the rhythmic flow of the renal system, but also contributed to increased detection of injuries. kidney in their urine. This result reveals a possible link between renal rhythmic function and renal damage. The paper was selected as APSselect article for March.

Non-traditional movement agendas-; hours outside the normal working day 9am to 5pm – has long been associated with many health disorders. More than 15 million Americans operate a shift agenda, according to the Centers for Disease Control and Prevention. However, no specific association has been identified between shift work and diseases such as high blood pressure, diabetes, and stroke.

The researchers’ findings are a “huge issue,” said study co-author Atlantis Hill, PhD, of Morehouse School of Medicine in Atlanta.

While there are many factors that contribute to the increased health risks associated with shift work, this study shows the link between organ rhythms and injury, highlighting the specific effects of an organ that is associated with long-term disruption of organ processes and a possible underlying cause for disease. common among shift workers. “

Atlantis Hill, Research Co-Author

Hill said the goal is for her team’s decisions to lead to targeted treatments and policies to prevent diseases that are common in people employed on a shift schedule.

Source:

American Psychological Association (APS)

Magazine Reference:

Hill, AM, et al. (2021) Environmental circadian disturbances induce rhythms in renal function and accelerate excretion of renal injury symptoms in the urine of hypertensive male rats. American Journal of Physiology-Renal Physiology. doi.org/10.1152/ajprenal.00421.2020.

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