RESULTS
A study led by researchers at the UCLA Jonsson Comprehensive Cancer Center has found that magnetic resonance imaging, or MRI, often underestimates the size of prostate tumors, which may lead to promise.
The authors of the study found that such misdiagnosis usually occurs when tumor size is measured with a small MRI and the PI-RADS score, which is used to classify lesions in analysis. MRI of the prostate, low.
For prostate tumor treatments to be successful, both MRI size measurement and PI-RADS score must be accurate as they allow physicians to accurately determine where tumors end and where the normal healthy stuff around them begins.
BACKGROUND
MRI is often used to diagnose and rule out prostate cancer. It is also increasingly being used as a means of delivering and directing new high-focus therapies that use freezing (cryotherapy), ultrasound (HIFU) and heat (laser ablation) to destroy cancerous tissue in the prostate while squeezing healthy tension.
METHOD
Researchers compared tumor size measured by MRI with true tumor size after prostate removal in 441 men treated for prostate cancer.
COMMENT
Improving the ability to predict better ablation will allow more successful treatments for men with prostate cancer and will help reduce the morbidity of prostate cancer treatment.
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AUTHORS
The senior author is Dr. Robert Reiter, professor of urology at UCLA’s David Geffen School of Medicine and director of UCLA’s prostate cancer program. The lead author is Dr. Aydin Pooli, clinical professor of urology at UCLA. Other authors are David Johnson, Drs. Joseph Shirk, Daniela Markovic, Dr. Taylor Sadun, Dr. Anthony Sisk, Amirhossein Bajgiran, Dr. Sohrab Mirak, Dr. Ely Felker, Alexa Hughes and Dr. Steven Raman, UCLA all.
PRAY
The study was published online in the Journal of Urology.
PROPERTY
The work was supported by the Integrated Diagnostics Program, a joint venture between UCLA’s Department of Radical Sciences and UCLA’s Department of Pathology and Laboratory Medicine.
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