KARACHI: There are some reactions after vaccine redness, swelling or pain around the injection site as usual. Fatigue, fever, headache and sore arms are also uncommon in the first three days after receiving the vaccine, German news agency DW reports. The usual vaccine reactions are usually mild and subside after a few days. They show that the vaccine works.
Accordingly, such routine vaccine reactions have been reported after receiving the Russian BioNTech-Pfizer, Moderna, AstraZeneca and Sputnik V vaccines, which are already in use.
In addition, there were also individual cases of occasional side effects after vaccination, such as allergic reactions. Overall, the approved vaccines are safe, according to the European Medicines Agency (EMA), the U.S. Food and Drug Administration (FDA) and the World Health Organization (WHO).
In some newer vaccines – mRNA vaccines are only a plan for part of the COVID-19 pathogen. Others are called vector vaccines that use harmless adenoviruses as carriers to absorb SARS-CoV-2 surface proteins, the spike protein, and thus stimulate the immune response.
According to DW in Germany, three vaccines are currently being developed in China. They are the vaccines from the companies called Sinovac Biotech CoronaVac vaccine, Sinopharm’s Vero vaccine and CanSino Biologics called Ad5-nCoV or Convidecia.
Only partial data on vaccine efficacy have been released from their phase II and III trials. Sinopharm was the first company to officially announce data in early 2020.
The position is still unclear regarding the consent of the vaccines. More than a million people have already been vaccinated with the Sinopharm vaccine, but this has been done either as part of studies or with an emergency license.
The Sinopharm vaccine called Vero is based on an inactivated virus. Phase III tests for Vero have been conducted in 10 countries around the world, including the United Arab Emirates, Bahrain, Peru, Morocco, Argentina, Jordan and Pakistan. Phase III tests for Vero have been conducted in 10 countries around the world, including the United Arab Emirates, Bahrain, Peru, Morocco, Argentina, Jordan and Pakistan. Referring to the Chinese doctor of the Daily Mail in the UK, he said that the Chinese vaccine Covid-19 Sinopharm is considered unsafe due to 73 side effects. Some of the side effects include blindness, high blood pressure and loss of taste and frequency of upset urine. This was reported in a blog published on the Chinese microblogging website Weibo, but since then that blog has been removed from the site. This was also reproduced by Taiwan News, Apple Daily and Vice of America. Chinese doctors described the information as misleading and misleading due to unnecessary hype.
BioNTech-Pfizer vaccine is produced jointly by Germany and the USA, BNT162b2 vaccine. Routine vaccine reactions such as fatigue and headache were less frequent and weaker in elderly patients. However, because this mRNA vaccine has been used, a few patients experienced a severe allergic reaction immediately after injection. One patient in the U.S. and two Britons even went into anaphylactic shock, associated with skin reddening and shortness of breath.
As these people had no previous illnesses or were unaware that they were allergic to certain vaccine ingredients, the British Medicines and Healthcare products Regulatory Agency (MHRA) has issued a special warning to people with sensory impairment. to a particular vaccine ingredient, or who have already undergone anaphylactic shock. , against getting the vaccine. Manufacturers see no direct link to the vaccine in the case of a U.S. physician with no previous illnesses who died from cerebral hemorrhage as a result of immune thrombocytopenia 16 days after receiving the vaccine. This happens when the immune system reduces the number of plates.
Headlines were made when 33 people died in Norway a few days after the first vaccination, all over 75 years of age and with very serious illnesses.
According to King’s College London 37 per cent of those who received the Pfizer vaccine in January experienced some pain and swelling at the injection site. Fourteen per cent of people receiving the first dose reported a fever, tremors and body aches within a few days. All tests and experiences confirm that the vaccine is safe and effective. But those who have been vaccinated must continue to monitor social distance as nothing provides 100 percent safety against Covid-19. Doctors have been advised to take paracetamol for the management of inflammation and symptoms of upper arm injury after vaccination. Some experts believe if fever and other symptoms appear after a mandatory Covid 19 job test.
According to CNN, certain side effects of the vaccine will go away in a day or two. But some may or may not report any side effects. In the case of those who do not get any side effects, that does not mean that the vaccine does not work. In most cases, side effects have been reported after the second dose. According to CNBC, high-grade fever lasting more than two days could be a hallmark of Covid-19 for which testing is mandatory. He confirmed to contact a physician to find out why any of the symptoms last longer than two days.
Another vaccine is the mRNA-1273, from the US company Moderna is also a gene-based vaccine.
During the clinical trials, participants underwent the vaccine well, according to the manufacturer and the trial authorities. The usual vaccination observations were only moderate or moderate and did not last long. However, nearly 10% of those vaccinated with mRNA-1273 became obese, according to an interim report by an independent study panel.
A severe allergic reaction to the Moderna vaccine is “rare,” according to the U.S. Centers for Disease Control and Prevention (CDC). The CDC bases that assessment on documentation of 4,041,396 doses of the vaccine administered between 21 December 2020 and 10 January 2021. 108 allergic reactions were recorded, but only 10 recipients were diagnosed. into anaphylactic shock. The CDC said none of the allergic reactions caused death.
Very few people who received the Moderna vaccine experienced facial nerve paralysis. It is possible that the side effects were not induced by the mRNA, but by lipid nanoparticles that are carriers for the mRNA and are later broken down by the body.
Isolated cases of facial paralysis, mostly temporary, occurred over time during the clinical trials of the BioNTech / Pfizer and Moderna vaccines, but also during ongoing vaccinations in Israel.
In the case of British-Swedish company AstraZeneca, an incident during clinical trials in September caused a shift because one person suffered spinal inflammation after receiving the vaccine. The trial was adjourned shortly until a panel of independent experts concluded that the swelling may not have been related to the vaccine. Furthermore, only routine vaccine reactions have occurred with the AstraZeneca vaccine. Again, vaccination reactions were less frequent and milder in the elderly. This is a vector vaccine.
In the case of Russia, as early as August 2020, the vector vaccine Gam-COVID-Vac (Sputnik V) was approved, but without waiting for stage III tests involving tens of thousands of subjects. Sputnik V uses two differently modified adenoviruses (rAd26-S and rAd5-S). Nevertheless, Sputnik V is already used in addition to Russia in many other countries, including Belarus, the UAE, India, Brazil and Argentina. In Argentina, routine immunization reactions occurred in 317 of a total of 32,013 vaccinated people, according to the Argentinian Ministry of Health. No adverse effects have been reported following Sputnik V vaccination.
All the risks and side effects recorded so far are just a glimpse of the past few months – this must be noted despite the hype surrounding the rapid development of the vaccine. The possible long-term effects of the individual vaccines are not yet known. Only the long-term studies that come with the vaccines around the world and that have continued since an agreement has been given will provide clarity.
