Published in ‘Gut ‘, The study found that associations between gut microbiota composition, levels of cytokines and inflammatory symptoms in patients with COVID-19 suggest that the gut microbiome is involved in COVID-19 intensity possibly through altered responses host security.
The researchers also suggest that gut microbiota dysbiosis after a disease outbreak may contribute to persistent symptoms, aka ‘prolonged COVID’, highlighting the need to understand how gut microorganisms are involved the inflammation and COVID-19.
The researchers, from the University of China in Hong Kong, collected blood and stool samples from 100 patients with COVID-19 between February and May 2020. In total, 274 stool samples were followed.
In identifying microbial species related to disease depth, find these F. prausnitziiAnd Bifidobacterium bifidumThey were negatively linked to their severity after switching to antibiotic use and patients ’age. The numbers of these bacteria remained low in the samples collected up to 30 days after infected patients cleared the virus from their bodies.
The report states: “The potential role of gut microorganisms in COVID-19 could allow the use of mosquito-based risk imaging to identify people at risk of severe disease or inflammatory symptoms. downstream such as multifactorial inflammation and Kawasaki-like disease in children.
“Based on several patients examined in this study for up to 30 days after clearance of SARS-CoV-2, the gut microbiota is likely to be significantly altered after recovery from COVID-19 .A report of a subset of patients recovered with COVID -19 is experiencing persistent symptoms such as obesity, dyspnoea and joint pain, some over 80 days after symptoms develop. First, we claim that the dysbiotic gut microbiome may contribute to immune-related health problems after COVID-19. “
The study
First, the researchers compared the gut microbiota composition of the first stool samples of all COVID-19 patients (n = 87) with non-COVID-19 subjects (45 women to 33 men, 45.5 ± 17.4 years of age). age) to assess whether gut microbiota consistency is altered.
They found that members of the BacteroidetesThey were relatively abundant in patients with COVID-19 compared with non-COVID-19 (average 23.9% versus 12.8%), but ActinobacteriaThey were relatively abundant in non-COVID-19 individuals (26.1% vs. 19.0%).
Without control over antibiotic use, morphological differences in COVID-19 gut microbiota were largely driven by species enrichment including Ruminococcus gnavus, Torran RuminococcusAnd Bacteroides doreiAnd a reduction of Bifidobacterium Adocentis, Faecalibacterium prausnitziiAnd Eubacterium rectale.
When antibiotic effects were studied, differences between cohorts were significantly associated with support enrichment such as Parabacteroides, Sutterella wadsworthensisAnd Caccae bacteroidesAnd a reduction of Adlercreutzia equolifaciens, Dorea formicigeneransAnd Clostridium leptumIn COVID-19 compared with non-COVID-19, although the majority of the support contained was less than 0.1% of the mean dose in these samples.
Although the overall representation of gut microbiota differed between the 87 COVID-19 and 78 non-COVID-19 subjects, there were no significant differences in Shannon species richness and diversity.
The researchers note that the observational nature of the study means that they cannot establish cause and effect, and it is important to note that gut midges vary widely among different populations.
They also state that the short duration they follow does not allow the excretion of gut microbiota to lead to long-term persistent symptoms.
The report states: “Longer follow-up of patients with COVID-19 (3 months to 1 year after clearance of the virus) is required to address issues related to the duration of postrecovery dys microbiota gut, a link between microbiota dysbiosis and long-term persistent symptoms and whether dysbiosis or the enrichment / harassment of certain microorganisms revert individuals to future health problems. “
Source: Gut
doi: 10.1136 / gutjnl-2020-323020
“Gut microbiota concordance reveals depth of disease and intolerant immune responses in patients with COVID-19”
A view. CN, et al