Debilitating gut pain is quite common, but the underlying cause is not yet clear. It usually results from gut disease that stimulates immune responses. These can cause daily food to be considered harmful, causing severe and persistent pain.
New study, published in the journal Nature, reporting evidence from mice and humans that modern equipment contributes to gut pain.
Persistent gut pain
Pain occurs to warn the body and to protect it from tight or potential damage. There are three common forms of pain – nociceptive pain, caused by damage to body tension. Inflammatory pain, normal inflammation caused by an inappropriate response by the body’s immune system, and persistent pain, defined as pain lasting at least 12 weeks.
One of the most common causes of gut pain is irritable bowel syndrome (IBS), which causes depression, diarrhea, and asthma. The persistent pain in this condition is often attributed to allergies, but there is no definite cause and mechanism for why it occurs.
Often, the pain associated with IBS cannot be easily identified, and it is difficult to determine the cause or origin of the pain. People who have pain in their internal organs usually have difficulty not knowing the root cause. For example, IBS does not have specific disease symptoms, a condition that affects about 11 percent of the world’s population, which distinguishes one disease from another.
IBS can be triggered by risk factors such as imbalance in gut plants and gastroenteritis as a result of ingestion of contaminated food or water, stress, and changes in gut-brain communication.
The researchers of the study also found that bacterial infection can alter immune responses in the gut, as a result of which some foods are seen as harmful. As a result, the body absorbs the surrounding food and cigarettes, causing persistent gut pain.
The study
In the study, the researchers at the laboratory for Neuroimmune intestinal interactions, Interventional Research Center for Gastrointestinal Disorders, KU Leuven Division of Black Diseases, Metabolism and Aging in Belgium, explain the method new, where gut disease alters how the organ responds to antigens, found in many food items.
The immune system inside it detects that these antigens are harmful. As a result, people with IBS experience pain when eating food. They also showed that bacterial infection and bacterial toxins could stimulate an immune response that stimulates the production of diet-specific immunoglobulin E (IgE) antibodies in mice.
After ingestion of the antigen diet, visceral pain appeared. The pain sign came from the H1-mediated histamine receptor sensation of visceral relatives. Further, injection of food antigen, including wheat, soy, milk, and gluten, into the mucosa of patients with IBS stimulated local edema and mast cell activity, which are symptoms of inflammation.
Following an infection, the team also found that the egg white protein induced a chain reaction similar to what happens during a food allergy. The antigen binds itself to the IgE antibodies, which are attached to mast cells.
“Our results identify and identify peripheral apparatus that underlie food-induced abdominal pain, thus creating new opportunities for the treatment of irritable bowel syndrome and disorders. associated abdominal pain, ”the researchers in the study concluded.
Along with their findings, the researchers suggested several options for treatment. First, they suggested improving the intestinal barrier function to reduce the gut’s access to the intestinal immune system. Second, they suggested targeting IgE antibodies that can stimulate inflammation and are specific to the digestive tract, targeting the molecules released by the mast cells. Finally, they proposed to block the colonic sensory nerves that transmit information to the brain to cause pain.
The team said more research is needed to help develop a treatment to help people with IBS.