Chronic respiratory syndrome coronavirus (SARS-CoV-2) leads to an increase in troponin in nearly 50 percent of patients, which can be used as an indication of disease severity and pre-existing predict future cardiovascular events, a new study has found. Published in the U.S. National Institutes of Health and the European Journal of Heart, the research found that patients recovered from COVID-19 were more likely to suffer a myocardial injury due to troponin elevation.
Scientists took one hundred and forty-eight samples of covid-positive patients and used multi-parametric cardiovascular magnetic resonance (CMR) to assess myocardial injury in the hearts. “When you develop post-troponin-elevated COVID-19 infection, myocarditis-like injuries can be detected, with limited and minimal outcome,” the study said. There is also more evidence of possible persistent local inflammation, and survivors could cause long-term damage to the heart, especially after accessing intensive care, according to the patient. research.
[Consort diagram. CMR, cardiovascular magnetic resonance. Credit: European Heart Journal]
“During severe Covid-19 disease, there may be a direct impact on the heart. It is difficult to determine how the heart may be damaged, but MRI scans of the heart can identify different patterns of injury. , which could allow us to make more accurate judgments and focus more effective treatments, ”said Professor Marianna Fontana, a professor of cartography at University College London (UK), who led the research.
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Troponin levels linked to mortality
Severe respiratory disease such as COVID-19 is associated with elevated serum troponin levels, which are associated with mortality even after overdose. Elevated troponin, commonly found in hospitalized COVID-19 patients, can have side effects long after the person has recovered from coronavirus infection, scientists say. “Several methods that are dependent on troponin elevation have been proposed including congestive coronary syndrome, unmasking occult under cardiovascular disease, arrhythmias, myocarditis, or as part of systemic inflammatory syndrome,” the research showed. The multivariate study was conducted across six hungry hospitals, which ran 4 scanners on patients to assess the presence, type, and extent of myocardial injury using quality-controlled CMR. Patients who survived hospitalization of COVID-19 were found to have elevated serum troponin levels, which are released into the bloodstream as a result of heart muscle injury.
[Example of patient with a myocarditis-pattern. Credit: European Heart Journal]
Dr Graham Cole, a consultant cardiologist at Imperial College London, said: “Elevated troponin levels are associated with worse outcomes in Covid-19 patients.”
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