COVID-19 has a disproportionate effect on men compared to women. Could female hormones help improve clinical outcomes for certain men hospitalized with the disease? Recent research supports this view.
The study was inspired by multiple reports that men are at greater risk for mortality and serious illness from COVID-19 than women.
“As an ICU doctor, I was struck by the gender difference among COVID-19 patients who were critically ill, hospitalized and in need of ventilators,” said Dr. Sara Ghandehari, director of Rehabilitation Pulmonary at Cedars- Sinai Women’s Guild Lung Institute
She said: “In addition, some published studies have shown that premenopausal women, who generally have higher progesterone levels than postmenopausal women, have higher progesterone levels, lower COVID-19 infection. low.
“While the bodies of both men and women naturally produce progesterone, women make much more of the hormone during their reproductive years.”
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One trend that has emerged is the tendency for men to have a more difficult experience with the disease than women, Medical News said today.
The health site continued: “According to findings published earlier in Frontiers in public health, COVID-19 symptoms and complications are more severe in men than women.
“The ratio of COVID-19 deaths in men to those in women is 1.35.
“This means that for every 100 women who die, 135 men will die from the disease.
“The ratio rises and falls with age, reaching a height of 2.56 in the 60-69 age group. ”
Progesterone is excreted in the bodies of men and women, although women make much more of the hormone during their reproductive years.
Experts have also noticed that premenopausal women tend to experience less severe cases of COVID-19 than their postmenopausal peers.
It was also noted that, compared to the control group, patients who received the progesterone medications received a median 1.5 points higher on the scale.
The experimental group also had fewer hospital days and a lower need for additional oxygen and mechanical ventilation, although the team said that the differences between the groups in these areas were not statistically significant.
“While our findings are encouraging for the potential use of progesterone to treat men with COVID-19, there were significant limitations in our study,” Dr. Ghandehari said.
“Further research is needed in larger and more heterogeneous populations, including postmenopausal women and at other treatment centers, to establish the level of clinical efficacy and any other potential safety concerns. to evaluate this approach. “
Despite its widespread use in pregnancy it has also been shown that progesterone promotes zero repair, blood vessel and bone repair.