Antibodies for Covid-19 found in breast milk after vaccination

The Covid-19 vaccine recommendations for pregnant or breastfeeding women say they are “true. “However, the absence of prospective (or even retrospective) data in any of these groups means that all recommendations are based on what is considered to be safe and effective. Early concerns that the spike protein formed in the bloodstream mimics the placenta-binding protein, leading to pregnancy loss or infertility, were abruptly eliminated. Pregnant or nursing health care workers were also advised to proceed with the vaccine. Both the Centers for Disease Control (CDC) and the World Health Organization (WHO) have provided guidance for pregnant women, but, to date, no completed clinical trials have been conducted looking at efficacy and efficacy results. vaccine safety during pregnancy. These trials have begun with the Pfizer / BioNTech vaccine, and data should be forthcoming in the coming months.

But as many experts have said, one cannot reduce the risks of vaccination and efficacy in pregnant women with infertility. The mother’s transmission through the placental bloodstream to the fetus is different from the mother’s introduction of breast milk to the baby. In addition, because the fetus is constantly changing developmental stages in utero, the time at the time of transfer of a particular material can have a different effect. Intake of breast milk into the gastrointestinal tract of the baby will have a different effect and effect than its release from the placental blood supply to the fetus. Phase 2/3 vaccination tests in pregnant women follow pregnant mothers for 7 to 10 months after trial to better understand the development of SARS-CoV-2 antibodies for both both the mother and the baby after delivery.

Children are not yet eligible for any of the three vaccines available in the U.S., and are unlikely to be eligible for time. But they are still at risk of getting serious Covid-19 disease. Although young children have not been a major age group for severe illness or death, infants and young children can develop a serious inflammatory disease called MIS-C (multisystemic inflammatory syndrome in children), as a diagnosis of postpartum illness -coronavirus. Children with this syndrome present with high fever, fatigue, rash, myalgias (muscle pain), and sometimes heart problems. Many require hospitalization, and some have had access to secondary complications to MIS-C. This entity tends to be more common in infants and toddlers, who will be the last age groups to be licensed for Covid-19 vaccination.

While this season has not focused on flu issues, it is well documented that lactating mothers who receive the flu vaccine can protect against flu flu antibodies through fresh milk- birth or child. This provides some protection against influenza for babies under 6 months, who are too young to get the flu vaccine. Studies are currently being carried out to see if this would be true for SARS-CoV-2 antibodies in breastfed infants.

A recently released white paper includes a very small study looking for the presence of Covid-19 protective antibodies in lactating breast milk after the mother received a Covid-19 vaccine course. A group based at Providence Portland Medical Center in Oregon enrolled six lactating women who received the Pfizer / BioNTech or Moderna Covid-19 vaccine schedule between December 2020 and January 2021. All subjects completed the two-dose vaccination course, with 21- or 28-day course between the first and second vaccinations. Breast milk samples were obtained before the first vaccine dose, plus 11 additional time points, with the last sample collected at 14 days after the second vaccine dose.

The group found that, before seven days after the first vaccine dose, breast milk samples showed substantial IgG and IgA immunoglobulins against SARS-CoV-2. Breast milk antibody levels declined slightly in the weeks immediately before the second vaccine dose, but rose sharply and remained high after receiving the second vaccine dose. None of the women in the study had a previous history of Covid-19 infection. The significant difference in antibody levels in previously vaccinated against lactating women is that those with pre-infection showed significant IgA antibodies, and elevated IgG antibodies are predominant in milk. breast a vaccine vaccine.

IgA antibodies are widely present in the respiratory infectious mucous membrane, and are usually seen after respiratory illness. Immunoglobulin G, or IgG, is a more common blood-borne antibody, which provides systemic immunity, and is more easily seen after intramuscular injection compared with respiratory infection.

Although this study is relatively small, and the data on the duration of antibodies in breast milk are still predictable, it provides promising news that breastfed babies receive a level of protection at a time when they are not. Covid-19 vaccine available this age group.