An effective turbulent mixture, controlled for flow chemistry

The Uniqsis range of Glass Static Mixer (GSM) chip reactor blocks deliver efficient, turbulent mixed reagent flow for non-dispersion-dependent flow chemistry reactions.

To achieve a highly reproducible flow chemistry scale – mixing and temperature control are essential, especially for highly exothermic or rapid reactions, which rely on mixing.

Now available in sizes from 270µl to 20 ml, the recently expanded range of GSM chips from Uniqsis can be used to make reflexes from -80 ° C to over 150 ° C. GSM syringes up to 2 ml can be operated up to 40-bar and are available in 2-channel or 3-channel resolution. Larger GSM chips of 10ml and 20ml have premixing channels followed by a residential range and can operate up to 10-bar.

GSM chips can be used as mixing models before a coil reactor residence time unit, or as reactor blocks for rapid exothermic reactions such as nitrations. Nitration is an important synthetic technique that, after the reduction of the nitro group, provides a useful route for the incorporation of amino groups on fragrant rings. Uniqsis Application Note 22 describes how a GSM chip was used to control both temperature and mixing. Under these controlled conditions, selective mono-nitration was carried out rapidly at high temperatures to obtain the maximum.

Uniqsis GSM slots are meticulously engineered from inert borosilicate glass to withstand a wide temperature range and can be conveniently connected to FlowSyn column heater modules, Cold Coil, or Polar Bear Plus cryogenic reactor modules.

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