Masitinib, a tyrosine kinase inhibitor targeting mast cells and macrophages, showed significant effects on both psychiatry and daily activity as a diagnostic treatment in a phase IIb / III study of moderate to severe Alzheimer’s patients, makes AB Science drugs.
The YKL-40 protein linked Alzheimer’s disease to circadian rhythm dysfunction, suggesting that it may be targeted to reduce Alzheimer’s progression. (Science Translation Science)
A case series looked at ICU patients with true COVID-19 who remained in comatose states long after discontinuation of sedatives. (Neurology)
The S1 protein of SARS-CoV-2 readily overcame the blood-brain barrier in male mice. (Ignorance of nature)
Masks change the way people see faces. (Scientific Reports)
Johns Hopkins researchers released a report to help federal, state, and local policymakers reduce opioid overdose deaths during COVID-19 pandemics.
Brain size may affect the effectiveness of deep brain stimulation in patients with Parkinson’s disease. (Scientific Reports)
A card-based delirium detector has improved diagnostic accuracy when used with standard delirium screening devices. (Journal of the American Geriatrics Association)
Sleep latency predicted 7-year-old cognitive change in middle age to older Hispanic / Latino adults. (Alzheimer’s & Dementia)
Researchers targeted the National Football League for using racial norms to alter the mental scores of Black NFL players who had resigned, thus denying them compensation for related settlement claims to depression. (JAMA Neurology)
The “patience, love, and godliness” of Alzheimer’s care, recorded by a photographer in Iran. (STAT)