A well-known human study is the first to reveal strong links between specific gut microbes, diet and health, including weight

• The largest and most detailed study of this type found strong links between a person’s diet, the microbes in their gut (microbiome) and their health.
• Researchers have identified positively or negatively linked microbes (‘bad microbes’ and ‘good microphones’) with a person’s risk for certain serious illnesses, including diabetes and heart disease .
• Some of the microbes identified are so new that they have not yet been identified.
• These findings can be used to provide personalized diet advice for better health, based on a gut microbe test.

The PREDICT 1 study analyzed detailed data on the composition of gut microorganisms, their dietary habits, and cardiometabolic blood biomarkers. The researchers found evidence that the microbiome is linked to certain foods and diets, and that, in turn, some microbes in the gut are linked to biomarkers of metabolic disease. Surprisingly, the microbome is more closely related to these signals than other factors, such as genetics. Their report, authored by Dr. Francesco Asnicar (University of Trento) and Dr. Sarah Berry (King’s College London) and co – ordinated by Tim Spector (King’s College London) and Nicola Segata (University of Trento), appearing in Nature’s cure.

Dr. Sarah Berry, A Reader in Nutritional Sciences at King ‘s College London, said, “As a nutritionist, the discovery of novel microbes linked to specific foods, as well as metabolic health, is inspiring. However, our research suggests that we can modify our gut midges to increase our health by choosing the best foods for our particular biology. “

For example, the results show that there is a rich midge Prevotella copri and Blastocystis sex was associated with maintaining a favorable blood sugar level after a meal. Other species were associated with lower blood fat levels and symptoms of inflammation.

Professor Tim Spector, An epidemiologist from King’s College London, who started the PREDICT study program and is the scientific founder of ZOE explains, “When you eat, you don’t just nourish your body, you feed the trillions of microbes that live inside your gut. “

The researchers also found a strong association between the formation of gut midges with subjects with specific nutrition, diet, food groups and overall diet composition. The researchers found strong microbiome-based biomarkers on obesity, as well as indications for cardiovascular disease and glucose intolerance, which are key risk factors for COVID. These decisions can be used to help create personalized eating plans specifically designed to improve a person’s health.

“I am thrilled that we have been able to turn this cutting-edge science to experiment at home in the time it has taken for the research to be reviewed and published by peers,” says Spector. we can now give everyone a chance to find out which of those microbes they live in their gut. Using machine learning, we can share with you our calculations on how your body responds to any food. “

The researchers found that subjects who ate a diet rich in healthy plant-based foods were more likely to have high levels of good gut microbes. Conversely, diets containing plant-based foods were more likely to be associated with the ‘bad’ gut microbes.

“We were surprised to see such large, clear groups of what we informally call ‘good’ and ‘bad’ microbes emerging from our study,” he said. Nicola Segata, PhD, professor and principal investigator of the Computational Metagenomics Lab at the University of Trento, Italy and the director of the microbiome analysis in the study. “It’s also interesting to see that microbiologists know so little about many of these microbes that they haven’t even been named yet. This is now a big area of ​​focus for us, because we’re “Believing that they could open up new perspectives in the future on how we can use the gut midge as a changing target to improve people ‘s metabolism and health.”

PREDICT 1 was an international collaboration to study links between diet, the midges, and cardiometabolic health biomarkers. The researchers collected microbiome order data, detailed long-term diet information, and results of hundreds of cardiometabolic blood markers from just over 1,100 participants in the UK and the US PREDICT 2 completed their main studies in 2020 with 1,000 other US participants, and PREDICT 3 was launched a few months ago.

In ZOE

ZOE is a healthcare science company helping people understand their body’s responses to food. Using machine learning in conjunction with large-scale human studies, ZOE encodes the effects of nutrition on health. ZOE leads PREDICT Studies and the COVID Symptom Study, which are the world’s largest community research programs in nutrition and COVID-19 respectively.

Settled in London and Boston, ZOE was founded by Prof. Tim Spector of King’s College London, director of data science Jonathan Wolf and entrepreneur George Hadjigeorgiou. ZOE was named one of the Deloitte Fast 50 Rising Stars in 2019 for the company’s contribution to technology-enabled science and machine learning.

For more information on ZOE’s mission and science, visit joinzoe.com.

About a King”s London College

King’s College London is one of the top 10 universities in the world (QS World University Rankings, 2018/19) and among the oldest in England. King has more than 31,000 students (including more than 12,800 postgraduates) from some 150 countries around the world, and about 8,500 employees.

King has a unique reputation for world-class teaching and advanced study. In the 2014 Research Excellence Framework (REF), eighty-four per cent of King’s studies were rated as ‘world-leading’ or ‘internationally excellent’ (3 * and 4 *).

Since its inception, the King’s students and staff have dedicated themselves to the service of the society. King will continue to focus on world-leading education, research and service, and will have an increasingly proactive place in a more interconnected and complex world. Visit our website to find out more about Vision 2029, King’s strategic vision for the next 12 years to 2029, which will be the 200th anniversary of the university’s founding.

Opinions are changing around the world. The impact of life change. Kcl.ac.uk

About the University of Trento

The University of Trento is a vibrant, research-based university, with excellent teaching and research opportunities and excellent facilities. Today, the University (founded in 1962) is still small in size, but very good in quality, able to play a high profile role at European and international level.

In addition, the University’s 11 Departments and 3 Centers cover a wide range of academic subjects and specialisms. Most of the courses available at UniTrento are taught through the medium of English. This broad academic offering is aided by proven experience in dual, multi-level and combined degree organization.

In addition, national and international rankings place the University of Trento among the top Italian universities.

In addition, UniTrento participates in many research networks and has signed prestigious collaboration agreements with major research institutes and universities around the world. Young researchers and entrepreneurs from all over the world find fertile ground in Trento to create and develop start-up businesses.

For more information: https://www.unitn.it/en

SOURCE ZOE Health

Related Links

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