A new method for predicting individual risk of mental retardation

The early prognosis of older adults with a high risk for amnestic brain impairment (aMCI), using non-invasive and sensory neuro signals, is critical for early prevention of Alzheimer’s disease, the results of a new study suggested.

The study, published in the Journal of Alzheimer’s Disease, by researchers at the University of Kentucky establishes what they believe is a new way to predict risk years years before a clinical diagnosis is made. to do. Their work shows that direct measures of brain signals during mental activity are more sensitive and convincing signs of memory decline than conventional behavioral tests.

“Many studies have measured electrophysiologic rhythms at rest and sleep to predict Alzheimer’s risk. This study shows that a person’s mental risk can be better predicted when the brain is challenged In addition, we learned that out of thousands of possible brains.Oscillation steps, left-handed brain movements during working memory activities are called good predictors for risk of dementia, ”explained lead researcher Yang Jiang, an associate professor of behavioral sciences and an associate faculty member at the Sanders-Brown Center on Aging.

When looking for a particular car in a large parking lot, older people make more mistakes and take more time than young people due to brain and brain age. Jiang said it has already been reported that brain waves associated with that type of daily memory activity are different in the elderly who are normally conscious and those of patients with memory loss and depression.

For this new study, researchers followed healthy older adults for 10 years. They reported that a specific pattern of facial brain movements during daily memory work predicts a person’s risk of brain impairment about five years before a clinical diagnosis is made. This pattern was not observed in the elderly who remained normally conscious over the next 10 years.

Jiang said that prediction and prevention of mental decline is very important to allow for preventative measures, such as lifestyle changes, and for researchers to provide a better quality of life for the fast-growing population.

“Compared to conventional methods using neuroimaging such as biomarkers, this measurement method can be easily established in clinics, it is non-invasive, fast and affordable. Also, it is a reliable predictor of risk. mental decline in an individual. Our older partners are new. soon we will be able to get a better version of brainwave testing here in the UK. “

The clinical and translational work of this study was a team science effort by multiple researchers from the Sanders-Brown Center in the UK in terms of serving as coauthors including Erin Abner, Richard Kryscio, Greg Jicha, Fred Schmitt, Charles Smith, and colleagues from the Oak Ridge National Laboratory, University of Tennessee, and Institute of Psychology, Beijing China.

This project was presented to SBCoA by scientists at Oak Ridge National Laboratory co-author Nancy Munro to David Wekstein and Drs. William Markesbery and Charles Smith almost 15 years ago with funding from the Department of Energy. The research team received funding from NIH in recent years to expand this work in large and diverse numbers. Jiang said their long-term study confirms the importance of a successful Alzheimer’s research center in the UK.

Linda Van Eldik, director of the Sanders-Brown Center for Aging, said, “This places greater emphasis on the UK Sanders-Brown Center on Aging’s longstanding national and international reputation and the high quality of our researchers and research. they do. “

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This story was published from a wire group group with no text changes.

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