People with prediabetes have a higher than normal blood sugar level, and sometimes – but not always – go on to develop type 2 diabetes. Doctors should now be able to able to better manage that risk, thanks to a study identifying six different subtypes of prediabetes.
In a study covering 25 years of data and 899 individuals, researchers were able to classify these six subtypes through a series of biocontrollers, including glucose levels, liver fat, circulating fat body, blood lipid levels, and genetic risk.
These six subtypes (or “clusters”) carry different levels of risk when it comes to developing type 2 diabetes, which should help health professionals plan treatments to matching, as well as managing prediabetes and the secondary issues that come with it.
“For people with prediabetes it has not yet been possible to predict whether they would develop diabetes and be at risk for serious complications such as kidney failure, or whether they would be in a harmless form with slightly higher blood glucose levels but no significant risk. , ”says medical researcher Hans-Ulrich Häring of the German Diabetes Research Center (or DZD).
Groups 1, 2 and 4 represent a low-risk diabetes: they include participants who are not overweight, or who are overweight but have a relatively healthy metabolism. Accumulations 3, 5 and 6, meanwhile, are associated with an increased risk for diabetes and secondary infections.
Those in browser 3 naturally produce too little insulin, as well as showing other biomarkers such as higher median thickness (IMT) in their articles. Group 5 includes people who are more resistant to the effects of insulin and also with higher amounts of liver fat.
Those in browser 6 have higher levels of a specific type of body fat (visceral sinus and kidney). Although these people have a lower risk of developing diabetes compared to concentrations 3 and 5 , there is a higher risk of death and a greater chance of kidney failure in this group.
(DZD)
“As diabetes is evident, there are also different types of disease in the early stage of diabetes, which differ in blood glucose levels, insulin action and insulin secretion, body fat circulation , liver fat and genetic risk, “said diabetologist Robert Wagner, of DZD.
To further validate their findings, the researchers analyzed their data against an analysis of 6,810 records collected in the UK as part of a separate project. The same subtypes or aggregations were identified there, using similar markers and methods.
By experiencing how people differ in their likelihood of developing diseases, diabetes and complications can make a big difference compared to lump everyone together in the same group specific treatments to give prediabetes to specific risk groups.
With the growing number of people developing diabetes – worldwide as many as 700 million people could have type 2 diabetes by 2045 – and the situation as- causes millions of deaths every year, it is important to act as fast as we can.
“Next, in prospective studies, we will first try to determine the extent to which the new findings are relevant for the classification of individuals into risk groups,” says diabetologist Andreas Fritsche, of DZD. .
The research was published in Nature’s cure.