(DENVER – February 1, 2021, 10:00 am EST) The first comprehensive, prospective study of smoking habits in patients with non-small cell lung cancer (NSCLC) enrolled in a phase III phase III trial emerged. there was a high rate of smoking cessation and cessation after study entry, according to a study published today in the Journal of Thoracic Oncology. The JTO is the official journal of the International Society for the Study of Lung Cancer.
Persistent smoking after a lung cancer diagnosis is associated with a moderate increase of around 50% in mortality, according to the 2014 Surgeon General’s Report.
Dr. Conor Steuer, of the Winship Cancer Institute at Emory University in Atlanta, and colleagues conducted prospective assessments assessing patterns of tobacco use and cessation and the impact on outcomes. The study was conducted as part of the ECOG-ACRIN 1505 trial, which attempted to determine whether the introduction of bevacizumab into appropriate chemotherapy would improve total survival (OS) for patients with early-stage NSCLC. The first test protocol examined tobacco use patterns and the impact on overall outcomes as secondary endpoints.
The study examined 1,501 patients at baseline, three, six, nine, and twelve months with NSCLC enrolled in the 1505 EA trial. Of those surveyed, 90% reported a current or previous history of cigarette smoking , but before enrolling in a survey only 11% said they were currently smoking. For patients who reported smoking at the time of their lung cancer diagnosis but were no longer prior to the enrollment, enrollment time, 1% reported smoking at 12 months. Overall, 94% of respondents smoked cigarettes or less daily at 12 months.
Steuer stated that DFS for smokers compared to conventional and former smokers was never significantly different (HR 0.93, p = 0.64, HR 1.05, p = 0.72), but overall survival was improved. improvement for smokers (modified HR for death 0.54, p = 0.005, modified HR for death 0.68, p = 0.03), respectively.
“This is the first comprehensive, prospective report on smoking habits in NSCLC patients from an early stage III trial. There was a high rate of smoking reduction and cessation after study entry. There was no significant difference between DFS between smokers and smokers ever, however. there were fewer level 3-5 toxins and a more favorable OS in smokers, “Steuer concluded.
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About the IASLC:
The International Association for the Study of Lung Cancer (IASLC) is the only global organization dedicated to the study of lung cancer and other thoracic malignancies. Founded in 1974, the association’s membership includes nearly 7,500 lung cancer specialists across all disciplines in more than 100 countries, creating a global network working together to overcome lung and thoracic cancers all over the world. The association also publishes the Journal of Thoracic Oncology, the leading educational and informational publication for topics relevant to the prevention, detection, diagnosis, and treatment of all thoracic malignancy. Visit http: // www.
About the JTO:
JTO Clinical and Research Reports the official open journal of the International Society for the Study of Lung Cancer. This monthly publication expands the reach of the IASLC worldwide, offering the thoracic oncology community unprotected access.
Journal of Thoracic Oncology (JTO), the official journal of the International Society for the Study of Lung Cancer, the leading educational and informational publication for topics related to the prevention, detection, diagnosis, and treatment of all thoracic malignancy. JTO emphasizes a multidisciplinary approach and includes original research reviews and opinion pieces. The audience includes epidemiologists, medical oncologists, radiation oncologists, thoracic surgeons, pulmonologists, radiologists, pathologists, nuclear medicine physicians, and research scientists with a special interest in thoracic oncology.
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